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The effect of current Schistosoma mansoni infection on the immunogenicity of a candidate TB vaccine, MVA85A, in BCG-vaccinated adolescents: An open-label trial

Abstract:

Introduction
Helminth infection may affect vaccine immunogenicity and efficacy. Adolescents, a target population for tuberculosis booster vaccines, often have a high helminth burden. We investigated effects of Schistosoma mansoni (Sm) on the immunogenicity and safety of MVA85A, a model candidate tuberculosis vaccine, in BCG-vaccinated Ugandan adolescents.

Methods
In this phase II open label trial we enrolled 36 healthy, previously BCG-vaccinated adolescents, 18 with no ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pntd.0005440

Authors


Contributors

Role:
Editor
More from this funder
Name:
Wellcome Trust
Grant:
095780/Z/11/Z
095778
More from this funder
Name:
European Research Council
Grant:
FP7/2007-2013) EC-GA No 241642
Publisher:
Public Library of Science
Journal:
PLoS Neglected Tropical Diseases More from this journal
Volume:
11
Issue:
5
Pages:
e0005440
Publication date:
2017-05-04
Acceptance date:
2017-02-27
DOI:
ISSN:
1935-2735
Language:
English
Keywords:
Pubs id:
pubs:695681
UUID:
uuid:e78a5cdb-14dd-4e28-ae90-45473a7f981e
Local pid:
pubs:695681
Source identifiers:
695681
Deposit date:
2017-06-08

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