The effect of current Schistosoma mansoni infection on the immunogenicity of a candidate TB vaccine, MVA85A, in BCG-vaccinated adolescents: An open-label trial
Helminth infection may affect vaccine immunogenicity and efficacy. Adolescents, a target population for tuberculosis booster vaccines, often have a high helminth burden. We investigated effects of Schistosoma mansoni (Sm) on the immunogenicity and safety of MVA85A, a model candidate tuberculosis vaccine, in BCG-vaccinated Ugandan adolescents.
In this phase II open label trial we enrolled 36 healthy, previously BCG-vaccinated adolescents, 18 with no ...
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- Peer reviewed
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- Public Library of Science Publisher's website
- PLoS Neglected Tropical Diseases Journal website
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- Wajja et al.
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- © 2017 Wajja et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
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