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Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions.

Abstract:

The development of a highly effective vaccine remains a key strategic goal to aid the control and eventual eradication of Plasmodium falciparum malaria. In recent years, the reticulocyte-binding protein homolog 5 (RH5) has emerged as the most promising blood-stage P. falciparum candidate antigen to date, capable of conferring protection against stringent challenge in Aotus monkeys. We report on the first clinical trial to our knowledge to assess the RH5 antigen - a dose-escalation phase Ia st...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1172/jci.insight.96381

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
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National Institute for Health Research More from this funder
United States Agency for International Development More from this funder
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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
JCI Insight Journal website
Volume:
2
Issue:
21
Pages:
e96381
Publication date:
2017-11-05
Acceptance date:
2017-10-05
DOI:
EISSN:
2379-3708
Pubs id:
pubs:745705
URN:
uri:e78a48f4-8342-4453-ae74-020072d5f04d
UUID:
uuid:e78a48f4-8342-4453-ae74-020072d5f04d
Local pid:
pubs:745705
Language:
English
Keywords:

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