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Low pH and anionic lipid dependent fusion of Uukuniemi phlebovirus to liposomes.

Abstract:

Many phleboviruses (family Bunyaviridae) are emerging, medically important viruses. These viruses enter target cells by endocytosis and low pH dependent membrane fusion in late endosomes. However, the necessary and sufficient factors for fusion have not been fully characterized. We have studied the minimal fusion requirements of a prototypic phlebovirus, Uukuniemi virus, in an in vitro virus-liposome assay. We show that efficient lipid mixing between viral and liposome membranes requires clos...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.M115.691113

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Name:
European Research Council
Grant:
649053
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Name:
Wellcome Trust
Grant:
218080
More from this funder
Name:
Academy of Finland
Grant:
093305/Z/10/Z
Publisher:
American Society for Biochemistry and Molecular Biology
Journal:
Journal of Biological Chemistry More from this journal
Volume:
291
Pages:
6412-6422
Publication date:
2016-01-25
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Language:
English
Keywords:
Pubs id:
pubs:598082
UUID:
uuid:e783577f-d559-40eb-b612-27000cf53e53
Local pid:
pubs:598082
Source identifiers:
598082
Deposit date:
2016-02-07

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