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THE REAL McCOIL: A method for the concurrent estimation of the complexity of infection and SNP allele frequency for malaria parasites.

Abstract:

As many malaria-endemic countries move towards elimination of Plasmodium falciparum, the most virulent human malaria parasite, effective tools for monitoring malaria epidemiology are urgent priorities. P. falciparum population genetic approaches offer promising tools for understanding transmission and spread of the disease, but a high prevalence of multi-clone or polygenomic infections can render estimation of even the most basic parameters, such as allele frequencies, challenging. A previous...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


More from this funder
Name:
National Institutes of Health
Grant:
D43TW010132
More from this funder
Name:
Wellcome Trust
Grant:
090770/Z/09/Z
More from this funder
Name:
Bill and Melinda Gates Foundation
Grant:
OPP1132226
Publisher:
Public Library of Science
Journal:
PLoS Computational Biology More from this journal
Volume:
13
Issue:
1
Pages:
e1005348
Publication date:
2017-01-01
Acceptance date:
2017-01-05
DOI:
ISSN:
1553-7358
Language:
English
Keywords:
Pubs id:
pubs:675058
UUID:
uuid:e7822159-e9fc-483b-8369-66db092a9ce4
Local pid:
pubs:675058
Source identifiers:
675058
Deposit date:
2017-02-07

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