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THE REAL McCOIL: A method for the concurrent estimation of the complexity of infection and SNP allele frequency for malaria parasites.

Abstract:

As many malaria-endemic countries move towards elimination of Plasmodium falciparum, the most virulent human malaria parasite, effective tools for monitoring malaria epidemiology are urgent priorities. P. falciparum population genetic approaches offer promising tools for understanding transmission and spread of the disease, but a high prevalence of multi-clone or polygenomic infections can render estimation of even the most basic parameters, such as allele frequencies, challenging. A previous...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1371/journal.pcbi.1005348

Authors


Chang, H-H More by this author
Nankabirwa, J More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Computational Biology Journal website
Volume:
13
Issue:
1
Pages:
e1005348
Publication date:
2017-01-05
Acceptance date:
2017-01-05
DOI:
ISSN:
1553-7358
Pubs id:
pubs:675058
URN:
uri:e7822159-e9fc-483b-8369-66db092a9ce4
UUID:
uuid:e7822159-e9fc-483b-8369-66db092a9ce4
Local pid:
pubs:675058
Language:
English
Keywords:

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