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Diversity and dynamics of the minichromosomal karyotype in Trypanosoma brucei.

Abstract:

The genome of African trypanosomes contains a large number of minichromosomes. Their only proposed role is in the expansion of the parasites' repertoire of telomeric variant surface glycoprotein (VSG) genes as minichromosomes carry silent VSG gene copies in telomeric locations. Despite their importance as VSG gene donors, little is known about the actual composition of the minichromosomal karyotype and the stability of its inheritance. In this study we show, by using high-resolution pulsed-fi...

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Publication status:
Published

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Authors


Alsford, S More by this author
Wickstead, B More by this author
Ersfeld, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Molecular and biochemical parasitology
Volume:
113
Issue:
1
Pages:
79-88
Publication date:
2001-03-05
DOI:
EISSN:
1872-9428
ISSN:
0166-6851
URN:
uuid:e7808f09-7e8a-4186-90d2-b4e4ed949d43
Source identifiers:
9004
Local pid:
pubs:9004

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