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Dieting decreases plasma tryptophan and increases the prolactin response to d-fenfluramine in women but not men.

Abstract:
We studied the effect of 3 weeks of moderate calorie restriction on 5-HT-mediated prolactin (PRL) release in healthy volunteers using the 5-HT-releasing agent d-fenfluramine. In women, dieting significantly lowered plasma total and free tryptophan (TRP) and increased the PRL response to d-fenfluramine. None of these measures were altered in men who dieted. These findings add to the data indicating that dieting alters brain 5-HT function in women, perhaps as a consequence of reducing the availability of plasma TRP.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
Journal:
Journal of affective disorders
Volume:
33
Issue:
2
Pages:
89-97
Publication date:
1995-02-05
DOI:
EISSN:
1573-2517
ISSN:
0165-0327
URN:
uuid:e77ed392-33ee-4c95-a952-fdb76d5072ed
Source identifiers:
185992
Local pid:
pubs:185992

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