- Abstract:
- We studied the effect of 3 weeks of moderate calorie restriction on 5-HT-mediated prolactin (PRL) release in healthy volunteers using the 5-HT-releasing agent d-fenfluramine. In women, dieting significantly lowered plasma total and free tryptophan (TRP) and increased the PRL response to d-fenfluramine. None of these measures were altered in men who dieted. These findings add to the data indicating that dieting alters brain 5-HT function in women, perhaps as a consequence of reducing the availability of plasma TRP.
- Publication status:
- Published
- Publisher copy:
- 10.1016/0165-0327(94)00078-n
-
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- Journal:
- Journal of affective disorders
- Volume:
- 33
- Issue:
- 2
- Pages:
- 89-97
- Publication date:
- 1995-02-05
- DOI:
- EISSN:
-
1573-2517
- ISSN:
-
0165-0327
- URN:
-
uuid:e77ed392-33ee-4c95-a952-fdb76d5072ed
- Source identifiers:
-
185992
- Local pid:
- pubs:185992
- Language:
- English
- Keywords:
- Copyright date:
- 1995
Journal article
Dieting decreases plasma tryptophan and increases the prolactin response to d-fenfluramine in women but not men.
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