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High incidence of malaria in alpha-thalassaemic children.

Abstract:

The alpha+-thalassaemias are the commonest known human genetic disorders, affecting up to 80 per cent of some populations. Although there is good evidence from both epidemiological and clinical studies that these gene frequencies reflect selection by, and protection from, malaria, the mechanism is unknown. We have studied the epidemiology of malaria in childhood on the southwestern Pacific island of Espiritu Santo in Vanuatu and here we report that, paradoxically, both the incidence of uncomp...

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Publication status:
Published

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Publisher copy:
10.1038/383522a0

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Role:
Author
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Journal:
Nature
Volume:
383
Issue:
6600
Pages:
522-525
Publication date:
1996-10-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:e77e20cd-caf2-446b-ab83-08586907b3ab
Source identifiers:
25890
Local pid:
pubs:25890

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