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Biological predictors of clozapine response: a systematic review

Abstract:

Background: Clozapine is the recommended antipsychotic for treatment-resistant schizophrenia (TRS) but there is significant variability between patients in the degree to which clozapine will improve symptoms. The biological basis of this variability is unknown. Although clozapine has efficacy in TRS, it can elicit adverse effects and initiation is often delayed. Identification of predictive biomarkers of clozapine response may aid initiation of clozapine treatment, as we... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
ORCID:
0000-0003-4640-699X
Publisher:
Frontiers Media SA
Journal:
Frontiers In Psychiatry More from this journal
Volume:
9
Article number:
327
Publication date:
2018-07-26
Acceptance date:
2018-06-29
DOI:
EISSN:
1664-0640
ISSN:
1664-0640
Pmid:
30093869
Language:
English
Keywords:
Pubs id:
pubs:894331
UUID:
uuid:e77d57ce-4fad-44ba-9b35-f09ecc48888e
Local pid:
pubs:894331
Source identifiers:
894331
Deposit date:
2019-04-01

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