Journal article
Whither vaccines?
- Abstract:
- Currently used vaccines have had major effects on eliminating common infections, largely by duplicating the immune responses induced by natural infections. Now vaccinology faces more complex problems, such as waning antibody, immunosenescence, evasion of immunity by the pathogen, deviation of immunity by the microbiome, induction of inhibitory responses, and complexity of the antigens required for protection. Fortunately, vaccine development is now incorporating knowledge from immunology, structural biology, systems biology and synthetic chemistry to meet these challenges. In addition, international organisations are developing new funding and licensing pathways for vaccines aimed at pathogens with epidemic potential that emerge from tropical areas.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
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(Preview, Accepted manuscript, pdf, 300.5KB, Terms of use)
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- Publisher copy:
- 10.1016/S0163-4453(17)30184-6
Authors
- Publisher:
- Elsevier
- Journal:
- Journal of Infection More from this journal
- Volume:
- 74
- Pages:
- S2-S9
- Publication date:
- 2017-06-21
- Acceptance date:
- 2016-11-28
- DOI:
- EISSN:
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1532-2742
- ISSN:
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0163-4453
- Keywords:
- Pubs id:
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pubs:710829
- UUID:
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uuid:e770e90b-d263-4377-8845-afa14b1f5d26
- Local pid:
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pubs:710829
- Source identifiers:
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710829
- Deposit date:
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2017-12-18
Terms of use
- Copyright holder:
- British Infection Association
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/S0163-4453(17)30184-6
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