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An HLA class I specific monoclonal antibody that fails to bind to all HLA-A antigens.

Abstract:

A monoclonal antibody, MHM.5, specific for HLA class I antigens, bound to lymphocytes of all donors tested and was thought to bind to a monomorphic determinant. When the antibody was used to precipitate 35S methionine labeled HLA class I molecules from lymphoid cells, which were then isoelectric focused, it was found that the HLA-A1,A2 and A3 antigens were not precipitated. Similarly, MHM.5, which is IgG1, failed to block complement mediated lysis by alloantisera specific for HLA-A1, 2 and 3,...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Human immunology More from this journal
Volume:
13
Issue:
1
Pages:
13-19
Publication date:
1985-05-01
DOI:
EISSN:
1879-1166
ISSN:
0198-8859
Language:
English
Keywords:
Pubs id:
pubs:42375
UUID:
uuid:e770cefa-0381-46a8-83a6-82636f915359
Local pid:
pubs:42375
Source identifiers:
42375
Deposit date:
2012-12-19

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