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Subthalamic nucleus activity optimizes maximal effort motor responses in Parkinson's disease

Abstract:

The neural substrates that enable individuals to achieve their fastest and strongest motor responses have long been enigmatic. Importantly, characterization of such activities may inform novel therapeutic strategies for patients with hypokinetic disorders, such as Parkinson's disease. Here, we ask whether the basal ganglia may play an important role, not only in the attainment of maximal motor responses under standard conditions but also in the setting of the performance enhancements known to...

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Publisher copy:
10.1093/brain/aws183

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Brain More from this journal
Volume:
135
Issue:
9
Pages:
2766-2778
Publication date:
2012-09-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Language:
English
Keywords:
Pubs id:
pubs:352822
UUID:
uuid:e76ff7cc-1933-4a42-bafd-6c39326e2ef9
Local pid:
pubs:352822
Source identifiers:
352822
Deposit date:
2012-12-19

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