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Thesis

An evolutionary and functional analysis of the extended B7 family of costimulatory molecules

Abstract:

T cell activation requires antigen-independent costimulatory signals induced by the interaction of costimulatory molecules on an antigen-presenting cell (APC) with their receptors on the T cell. CD28 and CTLA-4 are both expressed at the T cell surface and mediate positive and negative signals respectively when engaged by their APCexpressed ligands, B7-1 and B7-2.

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Institution:
University of Oxford
Department:
Medical Sciences Division
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
2002
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
603826077
URN:
uuid:e769d4ab-81c9-4f92-918f-8ddfb718b596
Local pid:
td:603826077
Language:
English
Subjects:

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