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Parasite virulence and disease patterns in Plasmodium falciparum malaria.

Abstract:

Heterogeneity in parasite virulence is one of several factors that have been proposed to contribute to the wide spectrum of disease severity in Plasmodium falciparum malaria. We used observed age-structured patterns of disease to define a population structure of P. falciparum, where the latter contains several independently transmitted antigenic types or "strains" that each induce some degree of strain-specific antidisease immunity upon infection. Patterns of incidence of severe and mild dise...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.91.9.3715

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Kwiatkowski, D More by this author
Greenwood, AM More by this author
Greenwood, BM More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
91
Issue:
9
Pages:
3715-3719
Publication date:
1994-04-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:e7631373-0ee3-4cc9-8ae7-05d6aeb9237e
Source identifiers:
35800
Local pid:
pubs:35800

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