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Dobutamine-stress magnetic resonance microimaging in mice : acute changes of cardiac geometry and function in normal and failing murine hearts.

Abstract:

The aim of this study was to assess the capability of MRI to characterize systolic and diastolic function in normal and chronically failing mouse hearts in vivo at rest and during inotropic stimulation. Applying an ECG-gated FLASH-cine sequence, MRI at 7 T was performed at rest and after administration of 1.5 microgram/g IP dobutamine. There was a significant increase of heart rate, cardiac output, and ejection fraction and significant decrease of end-diastolic and end-systolic left ventricul...

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Publication status:
Published

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Publisher copy:
10.1161/01.res.88.6.563

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Journal:
Circulation research More from this journal
Volume:
88
Issue:
6
Pages:
563-569
Publication date:
2001-03-01
DOI:
EISSN:
1524-4571
ISSN:
0009-7330

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