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Thesis

Regulation of human RNA polymerase II CTD modifications

Abstract:

Transcription of human protein-coding genes and most small nuclear RNA genes is mediated by RNA Polymerase II (Pol II). During a cycle of transcription, Pol II recruits a variety of factors that facilitate transcription elongation, RNA processing and termination, through its long, unstructured C-terminal domain (CTD). The CTD in humans comprises 52 tandem heptapeptide repeats with the consensus sequence Y1S2P3T4S5P6S7

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Oxford college:
Brasenose College
Role:
Author

Contributors

Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Publication date:
2015
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:e745b5b6-8a4a-4b7a-81d7-499bca8bfea1
Local pid:
ora:11479
Deposit date:
2015-05-21

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