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Journal article

Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS: studies with [11C]flumazenil PET.

Abstract:

Five to ten percent of amyotrophic lateral sclerosis (ALS) cases are associated with mutations of the superoxide dismutase-1 (SOD1) gene, and the 'D90A' mutation is associated with a unique phenotype and markedly slower disease progression (mean survival time 14 years). Relative sparing of inhibitory cortical neuronal circuits might be one mechanism contributing to the slower progression in patients homozygous for the D90A mutation (homD90A). The GABA(A) receptor PET ligand [11C]flumazenil ha...

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Publication status:
Published

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Publisher copy:
10.1093/brain/awh509

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Brain : a journal of neurology More from this journal
Volume:
128
Issue:
Pt 6
Pages:
1323-1329
Publication date:
2005-06-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Language:
English
Keywords:
Pubs id:
pubs:373954
UUID:
uuid:e7423228-fa7e-47df-be93-4a0678597a10
Local pid:
pubs:373954
Source identifiers:
373954
Deposit date:
2013-11-16

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