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global sensitivity tool for cardiac cell modeling: Application to ionic current balance and hypertrophic signaling

Abstract:

Cardiovascular diseases are the major cause of death in the developed countries. Identifying key cellular processes involved in generation of the electrical signal and in regulation of signal transduction pathways is essential for unraveling the underlying mechanisms of heart rhythm behavior. Computational cardiac models provide important insights into cardiovascular function and disease. Sensitivity analysis presents a key tool for exploring the large parameter space of such models, in order...

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Journal:
Conf Proc IEEE Eng Med Biol Soc
Volume:
1
Pages:
1498-502
Publication date:
2010-01-01
URN:
uuid:e73f1dc3-7c36-48a4-85b1-3a0563aafcf4
Local pid:
cs:4217

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