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Journal article

The clinical and public health problem of relapse despite primaquine therapy: case review of repeated relapses of Plasmodium vivax acquired in Papua New Guinea.

Abstract:

BACKGROUND: Primaquine is the only drug available for preventing relapse following a primary attack by Plasmodium vivax malaria. This drug imposes several important problems: daily dosing over two weeks; toxicity in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency; partner blood schizontocides possibly impacting primaquine safety and efficacy; cytochrome P-450 abnormalities impairing metabolism and therapeutic activity; and some strains of parasite may be tolerant or resistan...

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Publication status:
Published online

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Publisher copy:
10.1186/1475-2875-13-488

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
Role:
Author
Journal:
Malaria journal
Volume:
13
Issue:
1
Pages:
488
Chapter number:
ARTN 488
Publication date:
2014-01-05
DOI:
EISSN:
1475-2875
ISSN:
1475-2875
URN:
uuid:e739a9c4-6073-4f48-935c-c38f8734cc54
Source identifiers:
503297
Local pid:
pubs:503297

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