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Journal article

Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM.

Abstract:
'Checkpoint' controls arrest the cell cycle after DNA damage, allowing repair to take place before mutations can be perpetuated. In multicellular organisms, DNA damage can also induce apoptotic cell death, protecting the organism at the expense of the individual cell. How does a cell 'choose' between cycle arrest and death? Analysis of two human tumour suppressor proteins, p53 and the ATM (ataxia-telangiectasia mutated) gene product, may provide some answers.
Publication status:
Published

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Journal:
Trends in biochemical sciences More from this journal
Volume:
20
Issue:
10
Pages:
426-430
Publication date:
1995-10-01
DOI:
ISSN:
0968-0004
Language:
English
Keywords:
Pubs id:
pubs:21778
UUID:
uuid:e7389da6-5b6c-40dd-b671-b36b00462ae9
Local pid:
pubs:21778
Source identifiers:
21778
Deposit date:
2012-12-19

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