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Tumour-stromal interactions in acid-mediated invasion: a mathematical model

Abstract:

It is well established that the tumour microenvironment can both promote and suppress tumour growth and invasion, however, most mathematical models of invasion view the normal tissue as inhibiting tumour progression via immune modulation or spatial constraint. In particular, the production of acid by tumour cells and the subsequent creation of a low extracellular pH environment has been explored in several ‘acid-mediated tumour invasion’ models where the acidic environment facilitates normal ...

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Publication date:
2010-01-01
URN:
uuid:e736f8a6-d18f-4033-ab66-bf84485cf3c7
Local pid:
oai:eprints.maths.ox.ac.uk:983

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