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Thesis

Functional characterisation of a novel heterozygous mutation in the transcriptional activation domain of the human FOXN1 gene

Abstract:

The competence of the human body to fight infections relies on lymphocytes, which differentiate in the thymus, a primary organ of the immune system. There, thymic epithelial cells (TECs) have a unique role to instruct developing T lymphocytes to discriminate self-proteins from foreign pathogens and react only against the latter. The development, function and maintenance of TECs are primarily dependent on the transcription factor FOXN1, which acts as a master regulator of the thymus organog...

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Division:
MSD
Department:
Paediatrics
Role:
Author

Contributors

Role:
Supervisor
Role:
Examiner
Role:
Examiner
More from this funder
Name:
Department of Paediatrics, University of Oxford
Funding agency for:
Rota, I
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2020-10-31

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