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Expression of perforin, granzyme A and Fas ligand mRNA in caecal tissues upon Eimeria tenella infection of naïve and immune chickens

Abstract:

Cytotoxic cells of the immune system may kill infected or transformed host cells via the perforin/granzyme or the Fas ligand (FasL) pathways. The purpose of this study was to determine mRNA expression of perforin, granzyme A and FasL inEimeria tenella-infected tissues at primary infection and infection of immune chickens as an indirect measure of cytotoxic cell activity. Chickens were rendered immune by repeated E. tenellainfections, which were manifested as an absence of clinical signs or pa...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/pim.12329

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More from this funder
Name:
Department for Environment, Food and Rural Affairs
Funding agency for:
Smith, A
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Funding agency for:
Smith, A
More from this funder
Name:
Jenner Institute
Funding agency for:
Smith, A
More from this funder
Name:
National Veterinary Institute Research Fund
More from this funder
Name:
Swedish Farmers’ Foundation for Agricultural Research
Publisher:
Wiley
Journal:
Parasite Immunology More from this journal
Volume:
38
Issue:
7
Pages:
419–430
Publication date:
2016-06-01
Acceptance date:
2016-04-22
DOI:
ISSN:
1365-3024
Subjects:
Pubs id:
pubs:629289
UUID:
uuid:e7165ed7-6124-4fcc-bc8c-3eb125b6a136
Local pid:
pubs:629289
Source identifiers:
629289
Deposit date:
2016-06-22

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