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Journal article

Identification of multiple quantitative trait loci linked to prion disease incubation period in mice.

Abstract:

Polymorphisms in the prion protein gene are known to affect prion disease incubation times and susceptibility in humans and mice. However, studies with inbred lines of mice show that large differences in incubation times occur even with the same amino acid sequence of the prion protein, suggesting that other genes may contribute to the observed variation. To identify these loci we analyzed 1,009 animals from an F2 intercross between two strains of mice, CAST/Ei and NZW/OlaHSd, with significan...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.101130398

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Strategic
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
98
Issue:
11
Pages:
6279-6283
Publication date:
2001-05-15
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:105341
UUID:
uuid:e715b472-e8c6-441f-848a-617c48aea8fc
Local pid:
pubs:105341
Source identifiers:
105341
Deposit date:
2012-12-19

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