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Journal article

Pharmacokinetics of high-dose oseltamivir in healthy volunteers.

Abstract:

The effects of loading doses and probenecid coadministration on oseltamivir pharmacokinetics at four increasing dose levels in groups of eight healthy adult Thai volunteers (125 individual series) were evaluated. Doses of up to 675 mg were well-tolerated. The pharmacokinetics were dose linear. Oseltamivir phosphate (OS) was rapidly and completely absorbed and converted (median conversion level, 93%) to the active carboxylate metabolite. Median elimination half-lives (and 95% confidence interv...

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Publication status:
Published

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Publisher copy:
10.1128/aac.00588-08

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Journal:
Antimicrobial agents and chemotherapy More from this journal
Volume:
53
Issue:
3
Pages:
945-952
Publication date:
2009-03-01
DOI:
EISSN:
1098-6596
ISSN:
0066-4804

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