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Journal article

Perhexiline.

Abstract:

Perhexiline, 2-(2,2-dicyclohexylethyl)piperidine, was originally developed as an anti-anginal drug in the 1970s. Despite its success, its use diminished due to the occurrence of poorly understood side effects including neurotoxicity and hepatotoxicity in a small proportion of patients. Recently, perhexiline's mechanism of action and the molecular basis of its toxicity have been elucidated. Perhexiline reduces fatty acid metabolism through the inhibition of carnitine palmitoyltransferase, the ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
Journal:
Cardiovascular drug reviews
Volume:
25
Issue:
1
Pages:
76-97
Publication date:
2007-01-01
DOI:
ISSN:
0897-5957
URN:
uuid:e70c91f7-12e5-4926-824a-007a315a2dc9
Source identifiers:
164446
Local pid:
pubs:164446

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