- Abstract:
-
The impact of human leukocyte antigen (HLA) mismatch after reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation (RIT) using unrelated donors (UD) is unclear, and may be modulated by T-cell depletion. We therefore examined outcomes of 157 consecutive patients undergoing RIT after uniform conditioning with fludarabine, melphalan, and alemtuzumab (FMC). Donors were 10/10 HLA-matched (MUDs, n = 107) and 6 to 9/10 HLA-matched (MMUDs, n = 50), with no significant differ...
Expand abstract - Publisher copy:
- 10.1182/blood-2010-01-265413
-
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- Journal:
- Blood
- Volume:
- 115
- Issue:
- 25
- Pages:
- 5147-5153
- Publication date:
- 2010-06-05
- DOI:
- EISSN:
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1528-0020
- ISSN:
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0006-4971
- URN:
-
uuid:e704fd61-5e37-4825-bb18-b35bf2232f52
- Source identifiers:
-
349547
- Local pid:
- pubs:349547
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
HLA-mismatched unrelated donors are a viable alternate graft source for allogeneic transplantation following alemtuzumab-based reduced-intensity conditioning.
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