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HLA-mismatched unrelated donors are a viable alternate graft source for allogeneic transplantation following alemtuzumab-based reduced-intensity conditioning.

Abstract:

The impact of human leukocyte antigen (HLA) mismatch after reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation (RIT) using unrelated donors (UD) is unclear, and may be modulated by T-cell depletion. We therefore examined outcomes of 157 consecutive patients undergoing RIT after uniform conditioning with fludarabine, melphalan, and alemtuzumab (FMC). Donors were 10/10 HLA-matched (MUDs, n = 107) and 6 to 9/10 HLA-matched (MMUDs, n = 50), with no significant differ...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Role:
Author
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Journal:
Blood
Volume:
115
Issue:
25
Pages:
5147-5153
Publication date:
2010-06-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:e704fd61-5e37-4825-bb18-b35bf2232f52
Source identifiers:
349547
Local pid:
pubs:349547

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