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The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration.

Abstract:

Dyslexia is one of the most prevalent childhood cognitive disorders, affecting approximately 5% of school-age children. We have recently identified a risk haplotype associated with dyslexia on chromosome 6p22.2 which spans the TTRAP gene and portions of THEM2 and KIAA0319. Here we show that in the presence of the risk haplotype, the expression of the KIAA0319 gene is reduced but the expression of the other two genes remains unaffected. Using in situ hybridization, we detect a very distinct ex...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddl089

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
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Journal:
Human molecular genetics
Volume:
15
Issue:
10
Pages:
1659-1666
Publication date:
2006-05-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:e702e9ba-97c7-449e-9792-392f30b49a3d
Source identifiers:
24438
Local pid:
pubs:24438

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