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Large variations in HIV-1 viral load explained by shifting-mosaic metapopulation dynamics

Abstract:

The viral population of HIV-1, like many pathogens that cause systemic infection, is structured and differentiated within the body. The dynamics of cellular immune trafficking through the blood and within compartments of the body has also received wide attention. Despite these advances, mathematical models, which are widely used to interpret and predict viral and immune dynamics in infection, typically treat the infected host as a well-mixed homogeneous environment. Here, we present mathemat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS Biology More from this journal
Volume:
14
Issue:
10
Article number:
e1002567
Publication date:
2016-10-05
Acceptance date:
2016-08-02
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
Language:
English
Keywords:
Pubs id:
pubs:641566
UUID:
uuid:e7008e6c-ce56-41b2-a316-1914108b9be2
Local pid:
pubs:641566
Source identifiers:
641566
Deposit date:
2016-09-05

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