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Alterations in receptor binding properties of recent human influenza H3N2 viruses are associated with reduced natural killer cell lysis of infected cells.

Abstract:

Natural killer (NK) cell recognition of influenza virus-infected cells involves hemagglutinin (HA) binding to sialic acid (SA) on activating NK receptors. SA also acts as a receptor for the binding of influenza virus to its target host cells. The SA binding properties of H3N2 influenza viruses have been observed to change during circulation in humans: recent isolates are unable to agglutinate chicken red blood cells and show reduced affinity for synthetic glycopolymers representing SA-alpha-2...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.01217-07

Authors


Journal:
Journal of virology More from this journal
Volume:
81
Issue:
20
Pages:
11170-11178
Publication date:
2007-10-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
pubs:33932
UUID:
uuid:e6ff01d7-cbb5-44c7-9d43-437f2df421e4
Local pid:
pubs:33932
Source identifiers:
33932
Deposit date:
2012-12-19

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