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PX- and FYVE-mediated interactions with membranes: simulation studies.

Abstract:

Molecular dynamics simulations have been used to explore the interactions of two PI(3)P-binding domains with their PI ligands and with a phospholipid bilayer. Three simulations each of the EEA1-FYVE domain and the p40(phox)-PX domain have been compared: with the protein in an apo state, with a bound Ins(1,3)P(2) molecule, and bound to a PI(3)P molecule embedded in a lipid bilayer. Two main questions were addressed in analysis of the simulations: (i) the location of these domains relative to t...

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Publication status:
Published

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Publisher copy:
10.1021/bi900435m
Journal:
Biochemistry More from this journal
Volume:
48
Issue:
23
Pages:
5090-5095
Publication date:
2009-06-01
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
Language:
English
Keywords:
Pubs id:
pubs:100700
UUID:
uuid:e6fa3ab9-9c2f-47ec-9eb4-af20967d82fa
Local pid:
pubs:100700
Source identifiers:
100700
Deposit date:
2012-12-19

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