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HIV T cell vaccines, the importance of clades.

Abstract:
Development of an HIV vaccine presents a formidable challenge. One of the unresolved, yet central issues is the importance of HIV variability. Here we argue that even with the recent focus on the induction of T cell-mediated immunity, HIV vaccines should match the local circulating HIV clades. Whether used alone or in a combination with vaccines eliciting HIV-neutralizing antibodies, efforts must be made to develop a T cell vaccine that stimulates a broad and long-lasting response.
Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Journal:
Vaccine More from this journal
Volume:
20
Issue:
15
Pages:
1918-1921
Publication date:
2002-05-01
DOI:
EISSN:
1873-2518
ISSN:
0264-410X

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