Journal article icon

Journal article

Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform

Abstract:

Statins are amongst the most widely prescribed drugs for those at risk of cardiovascular disease, lowering cholesterol levels by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Although effective in prevention of cardiovascular disease, statin use is associated with muscle weakness, myopathies and, in rare cases, fatal rhabdomyolysis. As simvastatin, a commonly prescribed statin, can promote Ca2+ release from sarcoplasmic reticulum (SR) vesicles, we investigated if simva...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1111/bph.14136

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Oxford college:
Trinity College
Role:
Author
ORCID:
0000-0001-7777-4985
Expand authors...
More from this funder
Funding agency for:
Russell, AJ
More from this funder
Funding agency for:
Calaghan, S
More from this funder
Funding agency for:
Sitsapesan, R
Publisher:
Wiley Publisher's website
Journal:
British Journal of Pharmacology Journal website
Volume:
175
Issue:
6
Pages:
938-952
Publication date:
2017-12-26
Acceptance date:
2017-12-13
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
Pubs id:
pubs:813101
URN:
uri:e6eaeae8-a00f-44ec-a5f7-ae2fff03b346
UUID:
uuid:e6eaeae8-a00f-44ec-a5f7-ae2fff03b346
Local pid:
pubs:813101

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP