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Journal article

A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.

Abstract:

Antibody 2G12 uniquely neutralizes a broad range of HIV-1 isolates by binding the high-mannose glycans on the HIV-1 surface glycoprotein, gp120. Antigens that resemble these natural epitopes of 2G12 would be highly desirable components for an HIV-1 vaccine. However, host-produced (self)-carbohydrate motifs have been unsuccessful so far at eliciting 2G12-like antibodies that cross-react with gp120. Based on the surprising observation that 2G12 binds nonproteinaceous monosaccharide D-fructose w...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1002717107

Authors


Doores, KJ More by this author
Scanlan, CN More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
107
Issue:
40
Pages:
17107-17112
Publication date:
2010-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:e6e5b533-9754-4201-8a48-d740abc65d09
Source identifiers:
73332
Local pid:
pubs:73332

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