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Can nano-impacts detect single enzyme activity? Theoretical considerations and an experimental study of catalase impacts

Abstract:

Recent publications report the direct electrochemical detection of individual enzyme activity via collisions at microelectrodes, though `back of an envelope' calculations challenge the applicability of the experimental method. In the light of these studies, we present a comprehensive combined theoretical and computational analysis of the electrode response to a proximate and freely-diffusing enzyme generating an electroactive product. We further present experimental data for the enzyme catala...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1021/acscatal.6b02633

Authors


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Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
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Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
Karyakin, A. A. More by this author
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Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
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Funding agency for:
Sepunaru, Loir
Publisher:
American Chemical Society Publisher's website
Journal:
ACS Catalysis Journal website
Volume:
6
Issue:
12
Pages:
8313–8320
Publication date:
2016-11-01
Acceptance date:
2016-09-14
DOI:
EISSN:
2155-5435
Pubs id:
pubs:656886
URN:
uri:e6e48620-c765-45f8-8ed6-aee220951970
UUID:
uuid:e6e48620-c765-45f8-8ed6-aee220951970
Local pid:
pubs:656886

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