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ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury

Abstract:

We recently discovered a novel role for neuregulin‐1 (Nrg1) signaling in mediating spontaneous regenerative processes and functional repair after spinal cord injury (SCI). We revealed that Nrg1 is the molecular signal responsible for spontaneous functional remyelination of dorsal column axons by peripheral nervous system (PNS)‐like Schwann cells after SCI. Here, we investigate whether Nrg1/ErbB signaling controls the unusual transformation of centrally derived progenitor cells into these func...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1002/glia.23586

Authors


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Role:
Author
ORCID:
0000-0002-6162-3485
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Oxford college:
Green Templeton College
Role:
Author
ORCID:
0000-0002-7996-2696
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Publisher:
Wiley Publisher's website
Journal:
Glia Journal website
Volume:
67
Issue:
6
Pages:
1036-1046
Publication date:
2019-01-13
Acceptance date:
2018-12-20
DOI:
EISSN:
1098-1136
ISSN:
0894-1491
Pubs id:
pubs:965726
URN:
uri:e6df071c-fdc1-4532-ab12-335ad2ad7271
UUID:
uuid:e6df071c-fdc1-4532-ab12-335ad2ad7271
Local pid:
pubs:965726

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