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NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation.

Abstract:

Nucleotide-binding oligomerization domain-containing-2 (NOD2) acts as a bacterial sensor in dendritic cells (DCs), but it is not clear how bacterial recognition links with antigen presentation after NOD2 stimulation. NOD2 variants are associated with Crohn's disease, where breakdown in self-recognition of commensal bacteria leads to gastrointestinal inflammation. Here we show NOD2 triggering by muramyldipeptide induces autophagy in DCs. This effect requires receptor-interacting serine-threoni...

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Publication status:
Published

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Publisher copy:
10.1038/nm.2069

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Journal:
Nature medicine
Volume:
16
Issue:
1
Pages:
90-97
Publication date:
2010-01-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:e6cea293-2f96-4b13-8611-fcb15c5fd92f
Source identifiers:
35006
Local pid:
pubs:35006

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