Characterisation of astrocyte diversity in the multiple sclerosis motor cortex

Thesis

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system where neurodegeneration often leads to irreversible disability. Clinical and pathological heterogeneity is the rule, with genetic (e.g. HLA-DRB1*15 status) and environmental factors playing important roles. The mechanisms underlying such heterogeneity remain elusive. Astrocytes, which are involved in MS pathogenesis, are an attractive candidate to contribute to such variation in MS patholo...

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Authors: Yee, S

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Subjects: Proteomics; Nervous system--Diseases; Astrocytes; Multiple sclerosis; Degeneration (Pathology)