Comparison of tests for association and linkage in incomplete families.

Journal article

To analyze incomplete families, the following statistical tests can be used: LRAT-a simple likelihood-based association test, TRANSMIT, SIBASSOC/STDT, and RCTDT. We compared these four tests, for the diallelic case, on simulated data sets. The comparisons focused on the power to detect linkage and association when different familial structures, resistance to population stratification, resistance to misclassification of the disease status of the healthy sib, and the effect of nonpaternity were...

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Authors: Cervino, A; Hill, A

• Publication status: Published
• Journal: American journal of human genetics
• Volume: 67
• Issue: 1
• Pages: 120-132
• Publication date: 2000-07-01
• DOI: 10.1086/302992
• EISSN: 1537-6605
• ISSN: 0002-9297
• Language: English
• Keywords: Computer Simulation; Genes, Recessive; Models, Genetic; Genetic Diseases, Inborn; Child, Preschool; Alleles; Genetic Linkage; Humans; Bias (Epidemiology); Genes, Dominant; Adult; Female; Male; Nuclear Family; Chromosome Mapping; Likelihood Functions; Parents; Gene Frequency; Research Design; Software; Haplotypes; Linkage Disequilibrium