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Optogenetic activation of SST-positive interneurons restores hippocampal theta oscillation impairment induced by soluble amyloid beta oligomers in vivo

Abstract:

Abnormal accumulation of amyloid β oligomers (AβO) is a hallmark of Alzheimer's disease (AD), which leads to learning and memory deficits. Hippocampal theta oscillations that are critical in spatial navigation, learning and memory are impaired in AD. Since GABAergic interneurons, such as somatostatin-positive (SST+) and parvalbumin-positive (PV+) interneurons, are believed to play key roles in the hippocampal oscillogenesis, we asked whether AβO selectively impairs these SST+ and PV+ interneu...

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Publication status:
Not Published
Peer review status:
Not peer reviewed
Version:
Author's Original

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Publisher copy:
10.1101/465112

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Oxford college:
Worcester College
ORCID:
0000-0002-2566-5426
Publication date:
2018-11-07
DOI:
Pubs id:
pubs:951516
URN:
uri:e6bfb59e-bc6b-4058-acf0-3de9b744ed19
UUID:
uuid:e6bfb59e-bc6b-4058-acf0-3de9b744ed19
Local pid:
pubs:951516

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