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Regulation of growth differentiation factor 15 expression by intracellular iron.

Abstract:

Growth differentiation factor 15 (GDF15) is a divergent member of the transforming growth factor-beta superfamily and has been identified in different contexts as a hypoxia-inducible gene product and as a molecule involved in hepcidin regulation. The biology of iron and oxygen is closely related, and known regulatory pathways involving hypoxia-inducible factor (HIF) and iron-regulatory proteins (IRPs) are responsive to both these stimuli. We therefore sought to characterize the regulation of ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Journal:
Blood
Volume:
113
Issue:
7
Pages:
1555-1563
Publication date:
2009-02-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
10719

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