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The relative roles of continuous growth hormone-releasing hormone (GHRH(1-29)NH2) and intermittent somatostatin(1-14)(SS) in growth hormone (GH) pulse generation: studies in normal and post cranial irradiated individuals.

Abstract:

OBJECTIVES: Pulsatile GH release in humans is thought to involve the coordinated interaction of growth hormone-releasing hormone (GHRH) and somatostatin (SS). Disordered GH secretion is seen in most patients following high dose (> 30 Gy) cranial irradiation in childhood and could result from dysregulation of these hypothalamic hormones or reflect direct pituitary damage. We have used a peptide 'clamp' to assess the relative roles of continuous GHRH and intermittent SS in GH pulse generatio...

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Publication status:
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Authors


Achermann, JC More by this author
Hindmarsh, PC More by this author
Robinson, IC More by this author
Matthews, DR More by this author
Journal:
Clinical endocrinology
Volume:
51
Issue:
5
Pages:
575-585
Publication date:
1999-11-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:e6890931-5e87-4f6e-9a15-a78844467747
Source identifiers:
72894
Local pid:
pubs:72894

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