Thalamic glutamate levels as a predictor of cortical response during executive functioning in subjects at high risk for psychosis.

Journal article

CONTEXT: Alterations in glutamatergic neurotransmission and cerebral cortical dysfunction are thought to be central to the pathophysiology of psychosis, but the relationship between these 2 factors is unclear. OBJECTIVE: To investigate the relationship between brain glutamate levels and cortical response during executive functioning in people at high risk for psychosis (ie, with an at-risk mental state [ARMS]). DESIGN: Subjects were studied using functional magnetic resonance imaging while th...

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Authors: Fusar-Poli, P; Stone, J; Broome, MR; Valli, I; Mechelli, A

• Journal: Archives of general psychiatry
• Volume: 68
• Issue: 9
• Pages: 881-890
• Publication date: 2011-09-01
• DOI: 10.1001/archgenpsychiatry.2011.46
• EISSN: 1538-3636
• ISSN: 0003-990X
• Language: English
• Keywords: Magnetic Resonance Spectroscopy; Psychiatric Status Rating Scales; Psychotic Disorders; Synaptic Transmission; Brain Mapping; Cerebral Cortex; Brain; Glutamic Acid; Magnetic Resonance Imaging; Female; Male; Executive Function; Thalamus; Humans; Adult; Psychomotor Performance