Novel therapeutic approaches targeting matrix metalloproteinases in cardiovascular disease.

Journal article

Matrix metalloproteinases (MMPs), are proteinases that participate in extracellular matrix remodelling and degradation. Under normal physiological conditions, the activities of MMPs are regulated at the level of transcription, of activation of the pro-MMP precursor zymogens and of inhibition by endogenous inhibitors (tissue inhibitors of metalloproteinases; TIMPs). Alteration in the regulation of MMP activity is implicated in atherosclerotic plaque development, coronary artery disease and hea...

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Authors: Briasoulis, A; Tousoulis, D; Papageorgiou, N; Kampoli, A; Androulakis, E

• Journal: Current topics in medicinal chemistry
• Volume: 12
• Issue: 10
• Pages: 1214-1221
• Publication date: 2012-01-01
• DOI: 10.2174/1568026611208011214
• EISSN: 1873-4294
• ISSN: 1568-0266
• Language: English
• Keywords: Animals; Ventricular Remodeling; Matrix Metalloproteinases; Humans; Cardiovascular Diseases; Matrix Metalloproteinase Inhibitors; Tissue Inhibitor of Metalloproteinases; Extracellular Matrix