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The severity of ankylosing spondylitis and responses to anti-tumour necrosis factor biologics are not influenced by the tumour necrosis factor receptor polymorphism incriminated in multiple sclerosis

Abstract:

Genetic polymorphism (rs1800693) of TNFRSF1A (type 1 tumour necrosis factor receptor) encodes a potentially anti-inflammatory soluble truncated form of the p55 receptor, which is associated with predisposition to multiple sclerosis but protection against ankylosing spondylitis (AS). We analysed 2917 UK Caucasian cases by linear and logistic regression for associations of rs1800693 with disease severity assessed by the Bath Ankylosing Spondylitis measures of disease activity and function (BASD...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41435-018-0017-0

Authors

More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
More authors...
More from this funder
Funding agency for:
Roberts, A
Vecellio, M
Grant:
20402
21428
21428
More from this funder
Funding agency for:
Vecellio, M
Grant:
21428
Thames Valley collaborative research network
Publisher:
Springer Nature
Journal:
Genes and Immunity More from this journal
Volume:
20
Pages:
167–171
Publication date:
2018-03-10
Acceptance date:
2017-12-11
DOI:
EISSN:
1476-5470
ISSN:
1466-4879
Pmid:
29535371
Language:
English
Pubs id:
pubs:820272
UUID:
uuid:e67c58ee-e2c2-4948-b8ba-2a461a84191a
Local pid:
pubs:820272
Source identifiers:
820272
Deposit date:
2018-04-20

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