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The severity of ankylosing spondylitis and responses to anti-tumour necrosis factor biologics are not influenced by the tumour necrosis factor receptor polymorphism incriminated in multiple sclerosis

Abstract:

Genetic polymorphism (rs1800693) of TNFRSF1A (type 1 tumour necrosis factor receptor) encodes a potentially anti-inflammatory soluble truncated form of the p55 receptor, which is associated with predisposition to multiple sclerosis but protection against ankylosing spondylitis (AS). We analysed 2917 UK Caucasian cases by linear and logistic regression for associations of rs1800693 with disease severity assessed by the Bath Ankylosing Spondylitis measures of disease activity and function (BASD...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41435-018-0017-0

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Karaderi, T More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Wordsworth, T More by this author
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Funding agency for:
Roberts, A
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Funding agency for:
Vecellio, M
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Grant:
Thames Valley collaborative research network
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Publisher:
Springer Nature Publisher's website
Journal:
Genes and Immunity Journal website
Volume:
20
Pages:
167–171
Publication date:
2018-03-10
Acceptance date:
2017-12-11
DOI:
EISSN:
1476-5470
ISSN:
1466-4879
Pubs id:
pubs:820272
URN:
uri:e67c58ee-e2c2-4948-b8ba-2a461a84191a
UUID:
uuid:e67c58ee-e2c2-4948-b8ba-2a461a84191a
Local pid:
pubs:820272
Language:
English

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