The emergence of drug-resistant malaria.

Journal article

Stochastic processes play a vital role in the early stages of the evolution of drug-resistant malaria. We present a simple and flexible method for investigating these processes and understanding how they affect the emergence of drug-resistant malaria. Qualitatively different predictions can be made depending on the biological and epidemiological factors which prevail in the field. Intense intra-host competition between co-infecting clones, low numbers of genes required to encode resistance, a...

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Authors: Hastings, I; Mackinnon, M

• Publication status: Published
• Journal: Parasitology
• Volume: 117 ( Pt 5)
• Issue: 5
• Pages: 411-417
• Publication date: 1998-11-01
• DOI: 10.1017/s0031182098003291
• EISSN: 1469-8161
• ISSN: 0031-1820
• Language: English
• Keywords: Models, Biological; Malaria; Mutation; Stochastic Processes; Drug Resistance