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Hypoxia-inducible factor pathway and diseases of the vascular wall.

Abstract:

BACKGROUND: Hypoxia may contribute to the pathogenesis of various diseases of the vascular wall. Hypoxia-inducible factors (HIFs) are nuclear transcriptional factors that regulate the transcription of genes that mediate cellular and tissue homeostatic responses to altered oxygenation. This article reviews the published literature on and discusses the role of the HIF pathway in diseases involving the vascular wall, including atherosclerosis, arterial aneurysms, pulmonary hypertension, vascula...

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Publication status:
Published

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Publisher copy:
10.1016/j.jvs.2013.02.240

Authors


Kiriakidis, S More by this author
Sandison, A More by this author
Paleolog, EM More by this author
Davies, AH More by this author
Journal:
Journal of vascular surgery
Volume:
58
Issue:
1
Pages:
219-230
Publication date:
2013-07-05
DOI:
EISSN:
1097-6809
ISSN:
0741-5214
URN:
uuid:e6652ac9-0766-4cfd-bc57-7c314271ba36
Source identifiers:
401225
Local pid:
pubs:401225

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