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Microanatomical correlates of cognitive ability and decline: normal ageing, MCI, and Alzheimer's disease.

Abstract:

Few microanatomical measures have been reliably correlated with cognitive measures in aging and Alzheimer's disease (AD), particularly in the early stages of degeneration, such as mild cognitive impairment (MCI). However, cortical minicolumn organization has been shown to correlate with cognitive ability in aging monkeys, and the present study extends this finding to humans. We have previously reported that minicolumn spacing of cells in human association cortex is selectively reduced in norm...

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Publication status:
Published

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Publisher copy:
10.1093/cercor/bhq264

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Journal:
Cerebral cortex (New York, N.Y. : 1991)
Volume:
21
Issue:
8
Pages:
1870-1878
Publication date:
2011-08-05
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
URN:
uuid:e64b5597-d8fc-4418-a91d-de5dae7a6fe2
Source identifiers:
186161
Local pid:
pubs:186161

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