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Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.

Abstract:

Patients with Peutz-Jeghers' syndrome (PJS) develop hamartomatous gastrointestinal polyps and characteristic pigmentation, as a result of germline mutations in the LKB1 gene. The hamartomas in PJS were long considered to be without malignant potential. There is, however, accumulating epidemiological evidence to suggest that PJS predisposes to cancers at several different sites (colon, pancreas, breast, ovary, testis, and cervix), although large enough patient samples are rarely available to p...

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Publication status:
Published

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Authors


Marchese, C More by this author
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Journal:
The Journal of pathology
Volume:
188
Issue:
1
Pages:
9-13
Publication date:
1999-05-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:e6440c50-47ec-471b-b6b8-c1a7d7071bb9
Source identifiers:
31518
Local pid:
pubs:31518

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