Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.

Journal article

Patients with Peutz-Jeghers' syndrome (PJS) develop hamartomatous gastrointestinal polyps and characteristic pigmentation, as a result of germline mutations in the LKB1 gene. The hamartomas in PJS were long considered to be without malignant potential. There is, however, accumulating epidemiological evidence to suggest that PJS predisposes to cancers at several different sites (colon, pancreas, breast, ovary, testis, and cervix), although large enough patient samples are rarely available to p...

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Authors: Wang, Z; Ellis, I; Zauber, P; Iwama, T; Marchese, C

• Publication status: Published
• Journal: Journal of pathology
• Volume: 188
• Issue: 1
• Pages: 9-13
• Publication date: 1999-05-01
• DOI: 10.1002/(sici)1096-9896(199905)188:1<9::aid-path326>3.0.co;2-e
• EISSN: 1096-9896
• ISSN: 0022-3417
• Language: English
• Keywords: Humans; Electrophoresis, Polyacrylamide Gel; Hamartoma; Polymerase Chain Reaction; Middle Aged; Adult; Alleles; Protein-Serine-Threonine Kinases; Disease Progression; Aged; Germ-Line Mutation; Carcinoma; Adenoma; Peutz-Jeghers Syndrome