Journal article
Low branched chain amino acids and tyrosine in Thai patients with type 2 diabetes mellitus treated with metformin and metformin-sulfonylurea combination therapies
- Abstract:
- Type 2 diabetes mellitus (T2DM) is a growing public health challenge for Thailand (current prevalence ~10.0%). Amino acids offer novel biomarkers to predict risk of T2DM and indicate sub-optimal disease management, which could facilitate earlier treatment. We studied amino acid profiles in a Thai cohort comprising of individuals with T2DM (n = 65 single-drug-treated; n = 38 multi-drug-treated) compared to healthy controls (n = 104) using liquid chromatography-mass spectrometry. Age and BMI were significantly lower in the healthy controls compared to the single or multi-treated T2DM groups. The BCAA (leucine and valine) were significantly lower in the single and multi-treated T2DM groups compared to healthy controls (p < 0.001 and p < 0.001) and isoleucine was significantly lower in the single-treated compared to the healthy controls (p = 0.014). These findings beg the question whether BCAAs supplementation be beneficial in T2DM patients treated with single or multi-drug therapy? Tyrosine was significantly lower in the single and multi-treated T2DM groups compared to healthy controls (p < 0.001 and p = 0.002), whereas phenylalanine was significantly higher in the multi-treated T2DM group compared to the single treated T2DM group (p = 0.045). We provide novel insights into the effects of diabetes treatments on these amino acids in insulin resistant states such as T2DM in a unique but understudied Thai population.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 290.4KB, Terms of use)
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- Publisher copy:
- 10.3390/jcm10225424
Authors
- Publisher:
- MDPI
- Journal:
- Journal of Clinical Medicine More from this journal
- Volume:
- 10
- Issue:
- 22
- Article number:
- 5424
- Publication date:
- 2021-11-20
- Acceptance date:
- 2021-11-18
- DOI:
- EISSN:
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2077-0383
- Pmid:
-
34830706
- Language:
-
English
- Keywords:
- Pubs id:
-
1212318
- Local pid:
-
pubs:1212318
- Deposit date:
-
2021-12-15
Terms of use
- Copyright holder:
- Sriboonvorakul et al.
- Copyright date:
- 2021
- Rights statement:
- ©2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
- Licence:
- CC Attribution (CC BY)
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