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Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems.

Abstract:

TLR3 recognizes double-stranded RNA, a product associated with viral infections. Many details of TLR3-induced mechanisms have emerged from gene-targeted mice or inhibition studies in transformed cell lines. However, the pathways activated in human immune cells or cells from disease tissue are less well understood. We have investigated TLR3-induced mechanisms of human primary cells of the innate immune system, including dendritic cells (DCs), macrophages (MØs), endothelial cells (ECs), and syn...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, BHF Centre of Research Excellence
Role:
Author
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Journal:
Blood
Volume:
110
Issue:
9
Pages:
3245-3252
Publication date:
2007-11-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:e63128c2-b728-4a67-99e0-c26f22f7aef2
Source identifiers:
224502
Local pid:
pubs:224502

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